0n Going Work
Microelectrode array (MEA) system is widely used in electrophysiological studies to understand electrical activities of neuronal cells. MEA devices containing multiple microelectrodes enable simultaneous recording of extracellular potentials from multiple cells and stimulating neurons to investigate neuronal interactions within neuronal network. Integrating with cell culture system, the MEA technology has various applications including disease modeling, drug screening, neurotoxicology study, and physical reservoir computing system.
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Home-Based Early Diagnosis of Prostate Cancer
Prostate cancer is one of the most common cancers among men worldwide. Currently, hospitals primarily use serum prostate-specific antigen (PSA) testing for screening. Our laboratory has developed a new technology utilizing electrochemical impedance sensors to analyze biomarkers in body fluids, enabling rapid and accurate preliminary diagnosis of prostate cancer (Pca) and benign prostatic hyperplasia (BPH). This method offers a non-invasive option and provides reliable data support for subsequent tissue examinations.
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Non-invasive flexible sensor system can continuously monitor various bio-medical information such as oxygen saturation, HR (Heart rate), HRV (Heart rate variable), and function of blood vessels (stiffness etc). This bio-medical information, when applied to deep learning-based platforms, is believed to contribute to an increase in the early diagnosis rate of various diseases (vascular disease, psychosis, etc.).
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Organic Electronic Chemical Transistor (OECT) systems are not only used for measuring changes in ions and blood glucose levels within the body but are also widely employed for monitoring natural water quality changes. OECTs, which include multiple independent transistor systems, enable the investigation of ions, sugars, and acidity from patient saliva, sweat, or blood. Various OECT applications are being researched and developed using flexible substrate materials to create skin.
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We are pursuing of balance monitoring between multi-neurotransmitters rather than simply monitoring multiple neurotransmitters. This can be the starting point for various intractable brain diseases, and the goal is to develop a tool that can balance neurotransmitters through drug delivery such as inhibitor or agonist.
Completed Research
- Flexible ElS sensor for detecting low-level multi-cholesterol in human saliva
- Multi-channel cuff-type nerve electrode with improved bio-compatibility
- Highly biocompatible fibrous ink-jet printable nerve electrode
- Foldable/multi-functional (cuff electrode, inflammation monitoring by glucose comsumption) nerve electrode
- Multi-layer, high-sensitive nano-porous platinum electrode material